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Bennett WM, Aronoff GR, Golper TA et al. Drug prescribing in renal failure: dosing guidelines for adults. Glucosamine: May enhance the antiplatelet effect of Agents with Antiplatelet Properties. When deciding whether to use NSAIDs on a regular basis, you have to weigh both your personal feelings and the medical facts.

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Constipation; diarrhea; dizziness; drowsiness; gas; headache; heartburn; nausea; stomach pain or upset; vomiting. Suppositories INDOCIN should not be prescribed for pediatric patients 14 years of age and younger unless toxicity or lack of efficacy associated with other drugs warrants the risk. American Academy of Family Physicians web site. This may indicate a more widespread infection that might require more than by mouth.

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See USP Controlled Room Temperature. What specialists treat rheumatoid arthritis RA? Chaudhuri RK, Pal A Jha TB. Conservation of Swertia chirata through direct shoot multiplication from leaf explants.

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Jafri, M. A. Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats. J Ethnopharmacol. As symptoms subside, the total daily dosage should be reduced to the lowest level required to control symptoms, or the drug should be discontinued. Avoid extravasation irritating to extravascular tissues.



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Campbell AN, Beasley JR, Kenna AP. Indomethacin and gastric perforation in a neonate. Lancet. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination. You are 60 or younger. Known hypersensitivity to indomethacin or any ingredient in the formulation. Aspirin is an NSAID but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines. The acute toxicity of Lasix has been determined in mice, rats and dogs. Because it appears in breast milk, caution should be exercised when furosemide is administered to a nursing mother. NSAIDs have never given you any side effects. Sodium Phosphates: May enhance the nephrotoxic effect of Nonsteroidal Anti-Inflammatory Agents. Specifically, the risk of acute phosphate nephropathy may be enhanced. Management: Consider avoiding this combination by temporarily suspending treatment with NSAIDs, or seeking alternatives to oral sodium phosphate bowel preparation. If the combination cannot be avoided, maintain adequate hydration and monitor renal function closely. In rat studies with NSAIDs, as with other drugs known to inhibit prostaglandin synthesis, an increased incidence of dystocia, delayed parturition, and decreased pup survival occurred. The effects of indomethacin on labor and delivery in pregnant women are unknown. Hypertension and worsening of preexisting hypertension reported; either event may contribute to the increased incidence of cardiovascular events.



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Smallhorn JF, Gow R, Olley PM et al. Combined noninvasive assessment of the patent ductus arteriosus in the preterm infant before and after indomethacin treatment. Am J Cardiol. When you leave the emergency department, take the medications as prescribed and keep your follow-up appointment. If you have any concerning signs or symptoms, call your doctor. If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, Lasix should be discontinued. Graham DJ. COX-2 inhibitors, other NSAIDs, and cardiovascular risk; the seduction of common sense. JAMA. Borderline elevations of 1 or more liver function tests can occur in up to 15% of patients taking NSAIDs, including this drug. These elevations may progress, remain unchanged, or may be transient with continued treatment. Elevations of ALT or AST of 3 or more times the upper limit of normal have been reported in about 1% of patients in clinical trials with NSAIDs. Rare cases of severe hepatic reactions, including jaundice, fatal fulminant hepatitis, liver necrosis, and hepatic failure, some with fatal outcomes, have been reported. Increases in serum potassium concentration, including hyperkalemia, have been reported with use of indomethacin, even in some patients without renal impairment. This effect helps to decrease swelling and pain. In late pregnancy, as with other NSAIDs, Suppositories INDOCIN should be avoided because they may cause premature closure of the ductus arteriosus. Ellison RC, Peckham GJ, Lang P et al. Evaluation of the preterm infant for patent ductus arteriosus. Pediatrics. The doctor should be able to decide what is appropriate. Tayel, A. A. and El Tras, W. F. Possibility of fighting food borne bacteria by egyptian folk medicinal herbs and spices extracts. J Egypt. Shoora, H. Pharmacological studies of cardamom oil in animals. Pharmacol. Concomitant use of cyclosporine and Lasix is associated with increased risk of gouty arthritis secondary to Lasix-induced hyperurecemia and cyclosporine impairment of renal urate excretion. Nonsteroidal anti-inflammatory drugs including indomethacin may rarely increase the risk for a heart attack or stroke. The risk may be greater if you have heart disease or increased risk for heart disease for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes or with longer use. This drug should not be taken right before or after heart bypass surgery CABG. HydrALAZINE: Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of HydrALAZINE. clomid



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When administered rectally, history of proctitis or recent rectal bleeding. Clinical studies have shown that indomethacin does not influence the hypoprothrombinemia produced by anticoagulants. However, when any additional drug, including indomethacin, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time. In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and indomethacin. Caution should be exercised when indomethacin and anticoagulants are administered concomitantly. The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone. Please refer to the for information on shortages of one or more of these preparations. The incidence for group 2 was based on reports in clinical trials, in the literature, and on voluntary reports since marketing. The probability of a causal relationship exists between indomethacin and these adverse reactions, some of which have been reported only rarely. NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients. Unlike aspirin, their effect on platelet function is quantitatively less, of shorter duration, and reversible. Patients receiving indomethacin who may be adversely affected by alterations in platelet function, such as those with coagulation disorders or patients receiving anticoagulants, should be carefully monitored. Corticosteroid interactions: nonsteroidal anti-inflammatory drugs NSAIDs. In: Hansten PD, Horn JR. Drug interactions and updates. The acute intragastric toxicity in neonatal rats is 7 to 10 times that of adult rats. Indomethacin may cause drowsiness; therefore, patients should be cautioned about engaging in activities requiring mental alertness and motor coordination, such as driving a car. Indomethacin may also cause headache. Headache which persists despite dosage reduction requires cessation of therapy with indomethacin. ferh.info bactrim



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Indomethacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Minerals with ADEK, Folate, Iron: May enhance the antiplatelet effect of Agents with Antiplatelet Properties. GI bleeding are at greater risk for serious GI events. Madhuri S, Pandey G. Some dietary agricultural plants with anticancer properties. Indomethacin affords relief of symptoms; it does not alter the progressive course of the underlying disease. clamoxin to order in usa



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CEO of the Arthritis Foundation in Atlanta. GI bleeding or ulceration, geriatric patients, smokers, those with alcohol dependence, and those in poor general health. Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics 2 Increase in cholesterol and triglyceride serum levels. AHFS drug information 2003. Schmidt B, Davis P, Moddemann D et al. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med. Mobacken, H. and Fregert, S. Allergic contact dermatitis from cardamom. In a double-blind comparative clinical study involving 175 patients with rheumatoid arthritis, however, the incidence of upper gastrointestinal adverse with indomethacin suppositories or indomethacin capsules was comparable. The incidence of lower gastrointestinal adverse effects was greater in the suppository group. Hussain AI, Anwar F Bhatti HN Rashid U. Phytochemical and in vitro anthelmintic screening of Butea frondosa and Swertia chirata from Pakistan. Ibritumomab. Both agents may contribute to impaired platelet function and an increased risk of bleeding. Psiorz, M. Production of amarogentin in root cultures of Swertia chirata. Planta Med. May cause headache. 341 420 Discontinue the drug in patients in whom indomethacin-induced headache persists despite a reduction in dosage. See the end of this Medication Guide for a list of prescription NSAID medicines.



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Who should not take NSAIDs? The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Carefully consider the potential benefits and risks of Suppositories INDOCIN and other treatment options before deciding to use Suppositories INDOCIN. If the ductus arteriosus closes or is significantly reduced in size after 48 hours or more from completion of first course, no further doses are necessary. If the ductus arteriosus reopens, a second course of 1 to 3 doses may be given; if unresponsive after 2 doses, surgery may be necessary. Chou R, Helfand M, Peterson K et al. Comparative effectiveness and safety of analgesics for osteoarthritis. Comparative effectiveness review no. 4. Prepared by the Oregon evidence-based practice center under contract no. 290-02-0024. Murray MD, Brater DC. Adverse effects of nonsteroidal anti-inflammatory drugs on renal function. Ann Intern Med. Take this medication by as directed by your doctor, usually 2 to 3 times a day with a full glass of water 8 ounces or 240 milliliters. not lie down for at least 10 minutes after taking this drug. If upset occurs while taking this medication, take it with food, milk, or an antacid. This information should not be used to decide whether or not to take indomethacin capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about indomethacin capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to indomethacin capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using indomethacin capsules. Tsai, Y. H. Crude drug zingiberaceae enhancement of percutaneous absorption of indomethacin: in vitro and in vivo permeation. Gaoxiong. There are also prescription strength NSAIDS. Thiazide and Thiazide-Like Diuretics: May enhance the nephrotoxic effect of Nonsteroidal Anti-Inflammatory Agents. Nonsteroidal Anti-Inflammatory Agents may diminish the therapeutic effect of Thiazide and Thiazide-Like Diuretics. F. Protect from freezing. synthroid contrareembolso



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Sengupta, A. Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice. Asian Pac. This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Usnic acid as an antibiotic. Accatino L, Pizarro M, Solis N, Koenig CS. Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat. Package not child resistant. Keep this and all drugs out of reach of children. Weinberger M. Analgesic sensitivity in children with asthma. Pediatrics. The principal signs and symptoms of overdose with Lasix are dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis, and are extensions of its diuretic action. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs. Awasthi AK, Bisht GS Anroop B. In vitro antimicrobial activity of Swertia chirata. Rajadurai VS, Yu VYH. Intravenous indomethacin therapy in preterm neonates with patent ductus arteriosus. J Paediatr Child Health. All patients receiving furosemide therapy should be observed for these signs or symptoms of fluid or electrolyte imbalance hyponatremia, hypochloremic alkalosis, hypokalemia, hypomagnesemia or hypocalcemia: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, arrhythmia, or gastrointestinal disturbances such as nausea and vomiting. Potential for spontaneous intraventricular hemorrhage in neonates. 301 Observe premature infants for signs of bleeding. The results of the mouse study and one of the three rabbit studies also showed an increased incidence and severity of hydronephrosis distention of the renal pelvis and, in some cases, of the ureters in fetuses derived from treated dams as compared with the incidence in fetuses from the control group. order generic flonase



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Risk of ocular toxicity. Are there other reasons you might not want to use NSAIDs regularly? Maximum 200 mg daily. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Al Kofahil, M. M. Element analysis and biological studies on ten oriental spices using XRF and Ames test. J Trace Elem. Lithium: Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of Lithium. Days 12 and 17 of gestation. McNeil. Motrin ibuprofen suspension, chewale tablets, caplets prescribing information. Fort Washington, PA; 1994 Dec. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to ephedrine. Using ephedrine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. If you are prescribed this drug on a regular schedule not just "as needed" and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. torsemide



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Jacob J, Gluck L, DiSessa T et al. The contribution of PDA in the neonate with severe RDS. J Pediatr. Kauppi, A. The Influence of Air Pollution on the Concentration of Airborne Elementsand on the Production of Stress-Ethylene in the Lichen Usnea hirtaL. Oral Lasix may be used in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with Lasix alone. Dobrescu D, Tanasescu M, Mezdrea A, et al. Contributions to the complex study of some lichens-Usnea genus. Pharmacological studies on Usnea barbata and Usnea hirta species. Simultaneous administration of sucralfate and Furosemide Injection may reduce the natriuretic and antihypertensive effects of furosemide. If you have trouble sleeping, ask your pharmacist or doctor about the best time to take this medication. False-negative results in the dexamethasone suppression test DST in patients being treated with indomethacin have been reported. Thus, results of the DST should be interpreted with caution in these patients. Ophthalmic effects: Prolonged therapy may cause corneal deposits and retinal disturbances, including those of the macula. Discontinue use with blurred or diminished vision and perform ophthalmologic exam. Periodically evaluate vision in all patients receiving long-term therapy. Beniwal, A. and Khetarpaul, N. Knowledge of consumers regarding the nature and extent of adulteration of Indian foods.



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Indomethacin, like other NSAIDs, can cause GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, which may result in hospitalization and even death. Although serious GI tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative sign or symptoms including epigastric pain, dyspepsia, melena, and hematemesis. The dosage is based on your medical condition and response to treatment. Adults should not use more than 200 milligrams per day. Impaired response to ACE inhibitors, angiotensin II receptor antagonists, β-blockers, and certain diuretics may occur. 420 508 See Specific Drugs under Interactions. The results of the mouse study and one of the three rabbit studies also showed an increased incidence and severity of hydronephrosis distention of the renal pelvis and, in some cases, of the ureters in fetuses derived from the treated dams as compared with the incidence in fetuses from the control group. Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior . This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction. For further information, see package insert for Capsules INDOCIN Indomethacin. does tesco cefpodoxime



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Indomethacin may aggravate depression or other psychiatric disturbances, epilepsy, and parkinsonism, and should be used with considerable caution in patients with these conditions. If severe CNS adverse reactions develop, indomethacin should be discontinued. Scartezzini, P. and Speroni, E. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol. Dosage is based on your medical condition and response to treatment. In adults, not use more than 200 milligrams per day. Wu WH, Liu LY, Chung CJ, et al. Estrogenic effect of yam ingestion in healthy postmenopausal women. Asthma, and Immunology web site. When indomethacin is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. Therefore, a lower total daily dosage of indomethacin may produce a satisfactory therapeutic effect. When increases in the dose of indomethacin are made, they should be made carefully and in small increments. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Remove foil wrapper. 2. Moisten suppository with water. 3. Insert pointed end first well into rectum. 4. If resistance to insertion is experienced, or suppository is expelled, the suppository may be inserted flat end first. 5. Prevention of expulsion may also necessitate holding the buttocks together. 6. If the suppository cannot be retained, discontinue use. Discuss the risks and benefits with your doctor. Keep your bridge or dentures clean. Your dentist can offer suggestions. Even if you do not have all of your original adult teeth, you can prevent new dental problems if you try these preventive tips. micronase



Binghamton, NY: Haworth Herbal Press, 1999

Urokinase: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Urokinase. The postural hypotension that sometimes occurs can usually be managed by getting up slowly. Wild yam is a plant. It contains a chemical, diosgenin, which can be made in the laboratory into various steroids, such as and DHEA. Avoid use in patients with recent MI unless benefits outweigh risk of cardiovascular thrombotic events. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of cardiovascular events; alternate therapies should be considered for patients at high risk. NSAIDs are not alike. They can have very different pros and cons. Talk to your doctor about the NSAID that might work best for you. It has been demonstrated that furosemide inhibits primarily the reabsorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone. Indomethacin is a non-steroidal anti-inflammatory drug NSAID that exhibits antipyretic and analgesic properties. Its mode of action, like that of other anti-inflammatory drugs, is not known. However, its therapeutic action is not due to pituitary-adrenal stimulation. Need to Buy indomethacin? You have had significant side effects from NSAIDs in the past. Renal calcifications from barely visible on x-ray to staghorn have occurred in some severely premature infants treated with intravenous furosemide for edema due to patent ductus arteriosus and hyaline membrane disease. The concurrent use of chlorothiazide has been reported to decrease hypercalcinuria and dissolve some calculi. Experts say that although severe brought on by orgasm are uncommon, men are three times as likely to get them as women. Borderline elevations of one or more liver tests may occur in up to 15% of patients taking NSAIDs including indomethacin. These laboratory abnormalities may progress, may remain unchanged, or may be transient with continuing therapy. Notable elevations of ALT or AST approximately three or more times the upper limit of normal have been reported in approximately 1% of patients in clinical trials with NSAIDs. In addition, rare cases of severe hepatic reactions, including jaundice and fatal fulminant hepatitis, liver necrosis and hepatic failure, some of them with fatal outcomes have been reported. Yeh TF, Raval D, Lilien LD et al. Decreased plasma glucose after indomethacin therapy in premature infants with patent ductus arteriosus. Lancet. The effects of furosemide on embryonic and fetal development and on pregnant dams were studied in mice, rats and rabbits. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use NSAIDs for a condition for which it was not prescribed. Do not give NSAIDs to other people, even if they have the same symptoms that you have. It may harm them. In some cases, the doctor may try an injection around the tooth for pain control. If there is swelling in the gums or face, or you have fever, antibiotics may be prescribed.



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On permanent teeth if the problem is severe, root canal therapy cleaning out the nerves and blood vessels and sealing off the root canals of the tooth and crown procedures are generally performed. Lin, C. C. Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage. Food Chem. Note: Use lowest effective dose for the shortest duration possible. THIS SECTION MAKES REFERENCE TO CAPSULE DOSAGE FOR GUIDANCE IN USING SUPPOSITORIES. The risks of NSAIDs have been highlighted in the media recently. But it's important to understand that, for many people, NSAIDs are a safe and effective treatment. The key is to work with your doctor. Together, you can weigh the benefits and risks and decide on the best treatment in your case.

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Indomethacin suppresses inflammation in rheumatoid arthritis as demonstrated by relief of pain and reduction of fever, swelling and tenderness. Improvement in patients treated with indomethacin for rheumatoid arthritis has been demonstrated by a reduction in joint swelling, average number of joints involved, and morning stiffness; by increased mobility as demonstrated by a decrease in walking time; and by improved functional capability as demonstrated by an increase in grip strength. Indomethacin may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis. In such instances the steroid dosage should be reduced slowly and the patients followed very closely for any possible adverse effects.

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Non-drug treatment for arthritis that is approved by your doctor such as weight loss if needed, strengthening and conditioning exercises may help improve your flexibility, range of motion, and joint function. Consult your doctor for specific instructions. Weber em. Mot. Transplanted in Urban Sites in Oulu, N. Finland. Arch Environ. This medicine may cause bleeding. Daily use of alcohol and may increase your risk for stomach bleeding, especially when combined with this medicine. Singh, J. Screening of various Swertia species extracts in primary monolayer cultures of rat hepatocytes against carbon tetrachloride- and paracetamol-induced toxicity.

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What are tips for living with rheumatoid arthritis? Morris, N. Detecting concentration differences in aromatic oils. Percept. Depression: Use caution with depression; use may aggravate depression or other psychiatric disorders. The chronic use of NSAIDs in women of reproductive age may be associated with infertility that is reversible upon discontinuation of the medication. Consider discontinuing use in women having difficulty conceiving or those undergoing investigation of fertility. The use of NSAIDs close to conception may be associated with an increased risk of miscarriage Bloor 2013; Bermas 2014.

Food and Drug Administration. Analysis and recommendations for agency action regarding non-steroidal anti-inflammatory drugs and cardiovascular risk. Smith IJ, Goss I, Congdon PJ. Intravenous indomethacin for patent ductus arteriosus. Arch Dis Child. To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the lowest effective dose for the shortest duration possible. Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even in the absence of previous CV symptoms. Patients should be informed about the symptoms of serious CV events and the steps to take if they occur.

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